Originally inhabited by the Ojibwa, Ottawa, and Potawatomi tribes, Mackinac County and the surrounding area was a vital hub for trade and cultural exchange. The arrival of French explorers in the 17th century marked the beginning of European influence, with the establishment of Fort Michilimackinac in 1715, a strategic military and trading post. The county's name is derived from the Native American word Mackinac, meaning turtle, referencing the shape of Mackinac Island. Throughout the 19th century, the region evolved with the fur trade, lumbering, and later tourism, driven by the area's natural beauty and historical significance.

Mackinac County features diverse geography & abundant natural beauty, featuring pristine forests, numerous inland lakes and rivers. Mackinac County is also unique in that it borders two Great Lakes: Lake Michigan & Lake Huron, with the Mackinac Bridge separating the two. Mackinac Island also sits within the county, which sees millions of visitors every year. The county's waterways, including the Straits of Mackinac, St. Marys River, and numerous inland lakes, provide critical habitats for various wildlife species, as well as beautiful seasonal and year-round real estate. Part of the Hiawatha National Forest also sits within Mackinac County.